Christian Lachance , M.D.
    Christian Lachance
    Research Axis
    Fetomaternal and Neonatal Pathologies Axis
    CHUSJ - Centre de Recherche

    514 345-4931 #6396

    Research Interests

    • Neurobiology of brain lesions complicating prematurity;
    • Free radical mediated injury in the premature infant.

    Ongoing Clinical Studies

    • The role of genetic thrombophilias in the genesis of periventricular brain hemorrhagic and ischemic lesions in premature infants;
    • Effects of inhaled corticosteroids (Fluticasone) on the evolution of Bronchopulmonary dysplasia in premature infants.

    Career Summary

    Neonatologist trained at University of Montreal, I completed my training in Basic Neuroscience in Dr Gordon Guroff’s lab at NICHD, NIH, USA and in Dr Phil Barker’s lab at the Montreal Neurological Institute. These studies focused on the biochemical and molecular mechanisms involved in apoptosis in the developing nervous system and more specifically on the role and signal transduction pathways of the p75 low affinity neurotrophin receptor both in neuronal and non neuronal cells.


    • Cell biology;
    • Primary neuronal and oligodendroglial cultures;
    • Cell death-survival assays;
    • Protein immunoanalysis (immunoblott, immunohistochemistry);
    • Signal transduction studies (in vitro and in vivo kinase assays, gene induction);
    • Basic molecular techniques;
    • Transgenic animals.

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