Silvia Selleri
    Silvia Selleri
    Research Axis
    Immune Diseases and Cancer Axis

    514 345-4931 #4583

    Research Project Title

    Immunobiology of hematopoietic stem cell transplants

    University Program



    Université de Montréal

    Research Interests

    Immunobiology of hematopoietic stem cell transplants

    Bone marrow transplantation is considered the gold standard when it comes to treating a large number of disorders and cancers related to the human immune system. In spite of a sharp rise in overall recipient survival rates over the last few years, mortality and morbidity rates for those being treated remain unacceptably high.

    Graft versus host disease (GVHD) is the primary cause of post-transplant morbidity and mortality after hematopoietic stem cell transplantation (HSCT) or lymphocyte transfusion. Silvia Selleri’s postdoctoral work focuses mainly on HSCT immunobiology as well as the physiology and possible immunomodulation of GVHD. She also intends to examine the dynamics of post-HSCT immune reconstitution and the feasibility of an immunotherapy approach in treating autoimmune diseases and cancers.

    Awards and Distinctions

    • 2012 Primary Immune Deficiencies Treatment Consortium (PIDTC) Fellowship award, National Institute of Allergy and Infectious Diseases and the Office of Rare Diseases Research (NIH)
    • 2012 Prize for Excellence for post-doctoral students, Foundation of Stars
    • 2009 Postdoctoral Scholarships for Excellence, Fondation CHU Sainte-Justine
    • 2005 Fontana Lionello Prize, Italian Foundation for Cancer Research, Milano

    Selected Publications

    • Selleri, S., Dieng, M.M., Nicoletti, S., Louis, I., Beausejour, C., Le Deist, F., Haddad, E.'' Cord blood-derived mesenchymal stromal cells down-modulate CD4+ T-cell activation by inducing IL-10 producing Th1 cells », Stem Cells Dev, 2012 Nov 20. PMID: 23167734
    • *Gregoire-Gauthier, J., *Selleri, S., Fontaine, F., Dieng, M.M., Patey, N., Despars, G., Beauséjour, C.M., Haddad, E. « Therapeutic efficacy of cord blood-derived mesenchymal stromal cells for the prevention of acute GVHD in a xenogenic mouse model '', Stem Cells Dev, 2012 Jul 1;21(10):1616- 26. (co-premier auteur)
    • Selleri S., Palazzo M., Deola S., Wang E., Balsari A., Marincola F.M., Rumio C. '' Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS '', Int Immunol. 2008 Aug;20(8):961-70.
    • Selleri S., Deola S., Pos Z., Jin P., Worschech A., Slezak S.L., Rumio C., Panelli M.C., Maric D., Stroncek D.F., Wang E., Marincola F.M. '' GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells '', J Transl Med. 2008 Apr 15;6:17.
    • Provenzano M.*, Selleri S.*, Jin P., Wang E., Werden R., Slezak S., Adams S.D., Panelli M.C., Leitman S.F., Stroncek D.F., Marincola F.M. '' Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals '', Cancer Immunol Immunother. 2007 Jul;56(7):1047-63. Epub 2006 Nov 24. (co-premiers auteurs)
    • Selleri S., Torchiana E., Pareyson D., Lulli L., Bertagnolio B., Savoiardo M., Farina L., Carrara F., Filocamo M., Gatti R., Sghirlanzoni A., Uziel G., Finocchiaro G. '' Deletion of exons 11-17 and novel mutations of the galactocerebrosidase gene in adult- and early-onset patients with Krabbe disease '', J Neurol. 2000 Nov;247(11):875-7.
    • Benedetti S., Pirola B., Pollo B., Magrassi L., Bruzzone M.G., Rigamonti D., Galli R., Selleri S., Di Meco F., De Fraja C., Vescovi A., Cattaneo E., Finocchiaro G. '' Gene therapy of experimental brain tumors using neural progenitor cells '', Nat Med. 2000 Apr;6(4):447-50.
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Created on 9/18/2014
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