Jean-Sébastien Joyal , M.D. , Ph.D.
    Jean-Sébastien Joyal
    Research Axis
    Metabolic and Cardiovascular Health Axis
    Research Theme
    Energy metabolism, stress and mitochondrial dysfunction

    514 345-4931 #3317



    • Full Time Assistant Professor, Department of Pediatrics, University of Montréal
    • Accredited Professor, Department of Pharmacology, University of Montréal
    • Adjunct Professor, Department of Pharmacology and Therapeutics, McGill University
    • Pediatric intensive care physician, CHU Sainte-Justine




    • Postdoc, Vascular biology and Ophthalmology, Harvard Medical School, 2013
    • PhD, Pharmacology, McGill University, 2011
    • Fellowship, Pediatric Cardiac Critical Care, Greet Ormond Street Hospital, London (UK), 2010
    • Fellowship, Pediatric Critical Care, CHU Sainte-Justine, 2007
    • Specialty, Pediatrics, CHU Sainte-Justine, 2004
    • MD, McGill University, 2000

    Research Interests

    Our laboratory explores the role of neuronal energy metabolism in physiologic and pathologic blood vessel growth. Understanding the drivers of abnormal vessel growth is key to controlling many diseases of the eye and cancer. In the retina, the oxygen and energy demands of neurons govern blood vessel growth. Although much is known about oxygen drivers of vessel development, surprisingly little is known about the neuronal energy signals that are also likely to control vessel growth. Our laboratory uses transgenic mice to study the driver of angiogenesis in models of proliferative retinopathy and age-related macular degeneration (AMD), together the leading cause of blindness. The eye is part of the central nervous system and consumes more energy than any other organ. It is therefore an excellent model in which to explore the metabolic crosstalk between neurons and vessels to discover new therapeutic targets.

    Research Topics

    • Angiogenisis
    • Neuro-vascular guidance
    • Cell signalling and GPCR
    • Neuronal energy metabolism
    • Murine models of proliferative retinopathy and cancer

    Awards and Distinctions

    • The Foundation Fighting Blindness, Operating Grant, 2014-2017
    • Burroughs Wellcome Fund (BWF) Career Awards for Medical Scientists, 2013-2018
    • Postdoctoral Fellowship – Canadian Institute of Health Research (CIHR), 2011-2013
    • Society of Pediatric Research PhD Award, 2009
    • Canadian Child Health Clinician-Scientist Program (CIHR), 2005-2009
    • Hemonstasis Research Fellowship (Canadian Blood Services and Novo Nordisk), 2004-2005

    Selected Publications

    Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, et al.
    Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
    Nature Medicine, March 14, 2016 (Article de page couverture et éditorial)
    Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, et al.
    Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.
    Nature Medicine, March 14, 2016 (Article de page couverture et éditorial)
    Joyal JS, Nim S , Zhu T, Sitaras N, Rivera JC, et al.
    Nuclear localization of Protease-activated receptor 2 dictates angiogenesis. 
    Nature Medicine, Sept 14, 2014 (co-corresponding)
    Stahl A*, Joyal JS*, Chen J, Boscolo E, Juan AM, et al.
    SOCS3 is an endogenous inhibitor of pathologic angiogenesis. 
    Blood, 2012 Oct 4;120(14):2925-9. (*Co-premier auteur; Article de page couverture)
    Joyal JS, Omri S, Sitaras N, Rivera JC, Duhamel F, et al. 
    Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and Semaphorin 3A. 
    Acta Pediatrica, 2012 Aug;101(8):819-26.
    Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, et al. 
    Ischemic neurons prevent vascular regeneration of neural tissue by secreting Semaphorin 3A. 
    Blood, 2011 Jun 2;117(22):6024-35. Epub 2011 Feb 25. (Article de page couverture et éditorial)
    Sapieha P, Joyal JS,  Rivera JC,  Kermorvant-Duchemin E, Sennlaub F, et al. 
    Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. 
    J Clin Invest., 2010 Sep 1;120(9):3022-32. Epub 2010 Sep 1.
    Sapieha P, Sirinyan M, Hamel D, Zaniolo K, Joyal JS, et al.  
    The succinate receptor GPR91 present on neurons, exerts a major role in retinal angiogenesis. 
    Nat Med, 2008 Oct;14(10):1067-76. Epub 2008 Oct 5.

Every dollar counts!

Thank you for your generosity.

It is thanks to donors such as you that we are able to accelerate research discoveries, to heal more children every year and to continue to offer world-class care.

It is also possible to give by mail or by calling toll-free

1-888-235-DONS (3667)

Contact Us

514 345-4931


© 2006-2014 CHU Sainte-Justine.
All rights reserved. 
Terms of Use,  Confidentiality,  Security


All information contained within the CHU Sainte-Justine site should not be used as a substitute for the advice of a duly qualified and authorized medical practitioner or any other health professional. The information provided on this site is intended for educational and informational purposes only.

Consult your physician if you feel ill or call 911 for any medical emergency.

CHU Sainte-Justine