Biography

    Carine Nyalendo , Ph.D.

    carine.nyalendo.hsj@ssss.gouv.qc.ca
    Research Axis
    Immune Diseases and Cancer Axis
    Address
    CHUSJ

    Phone
    514 345-4931 7988

    Fax
    514-345-4803

    Title

    • Clinical Assistant Professor, Biochemistry and Molecular Medicine Department, University of Montreal, 2017
    • Clinical Biochemist, Division of Biochemistry, CHU Sainte-Justine, 2013

    Education

    • Clinical Biochemistry Specialist Certificate (CSPQ), 2015
    • Postdoctoral Diploma (DEPD) - Clinical Biochemistry, University of Montreal, 2013
    • Doctorate (PhD) - Biochemistry, University of Quebec at Montreal, 2009

    Research Interests

    • Cancer stem cells and matrix metalloproteases in neuroblastoma
    • Pediatric reference intervals. Member of the CALIPER team (Canadian Initiative in Pediatric Reference Intervals)
    • Reference intervals in pregnancy  (The Mother-Child Study)
    • Development, evaluation and validation analytical methods

    Research Topics

    • Clinical Biochemistry
    • Reference intervals
    • Cancer stem cells
    • Tumor invasion
    • 3D matrix
    • Metalloproteases
    • Neuroblastoma

    Career Summary

    • Head of Clinical Chemistry Department, CHU Sainte-Justine, 2015-2017
    • Clinical Lecturer, Biochemistry and Molecular Medicine Department, University of Montreal,  2015-2017

    Selected Publications

    1. Delvin E, Alos N, Rauch F, Marcil V, Morel S, Boisvert M, Lecours MA, Laverdière C, Sinnett D, Krajinovic M, Dubois J, Drouin S, Lefebvre G, Samoilenko M, Nyalendo C, Cavalier E, Levy E. (2018) Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study. Clin Nutr. pii: S0261-5614(18)30069-4
    2. Belounis A, Nyalendo C, Le Gall R, Imbriglio TV, Mahma M, Teira P, Beaunoyer M, Cournoyer S, Haddad E, Vassal G, Sartelet H. (2016) Autophagy is associated with chemoresistance in neuroblastoma. BMC Cancer, 16(1):891.
    3. Liberman J, Sartelet H, Flahaut M, Mühlethaler-Mottet A, Coulon A, Nyalendo C, Vassal G, Joseph JM, Gross N. (2012) Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma. PLoS One, 7(8):e43665.
    4. Sartelet H, Imbriglio T, Nyalendo C, Haddad E, Annabi B, Duval M, Fetni R, Alexendrov L, Sinnett D, Fabre M, Vassal G. (2011) Expression of CD133 and poor outcome in neuroblastoma associated with chemoresistance mediated by AKT pathway. Histopathology, 60(7):1144-55.
    5. Sartelet H, Durrieu L, Fontaine F, Nyalendo C, Haddad E. (2012) Description of a new xenograft model of metastatic neuroblastoma using NOD/SCID/Il2rg Null (NSG) mice. In Vivo, 26(1):19-29.
    6. Nyalendo C, Sartelet H, Gingras D, Béliveau R. (2010) Inhibition of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation blocks tumor progression in mice. Anticancer Res, 30(6):1887-95.
    7. Nyalendo C, Sartelet H, Barette S, Ohta S, Gingras D, Béliveau R. (2009) Identification of phosphorylated membrane-type 1 matrix metalloproteinase in association with neuroblastoma progression. BMC Cancer, 9(1):422.
    8. Nyalendo C, Beaulieu E, Sartelet H, Michaud M, Fontaine N, Gingras D, and Béliveau R. (2008) Impaired tyrosine phosphorylation of membrane type 1-matrix metalloproteinase reduces tumor cell proliferation in three-dimensional matrices and abrogates tumor growth in mice. Carcinogenesis, 29(8): 1655–64.
    9. Nyalendo C, Michaud M, Beaulieu E, Roghi C, Murphy G, Gingras D, and Béliveau R. (2007) Src-mediated phosphorylation of membrane-type 1 matrix metalloproteinase on its residue tyrosine 573: role in endothelial and tumour cell migration. J Biol Chem, 282(21): 156690-9.
 

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