Lionel Carmant , M.D.
    Lionel Carmant
    Research Axis
    Brain and Child Development Axis
    Research Theme
    Neurodevelopmental diseases

    514 345-4931 #6106

    514 345-4787

    Career Summary

    My research focuses on the mechanisms of seizure-induced brain damage and how to prevent it. I use both clinical research and basic sciences to study the mechanisms involved with the use of novel antiepileptics, the use of surgery, and the study of the neuropsychological impact of seizures in human development.

    In the laboratory, I use both in vivo and in vitro studies to develop new possible treatments for the control of seizures and seizure-induced brain damage, but also to understand the pathophysiology of such a complex process.

    I have focused on the role of intracellular calcium stores and their release by metabotropic glutamate receptors. In vivo, I use video-EEG monitoring of the rats exposed to kainic acid, tests of neuropsychological functions, mainly the Morris water maze, as well as neuropathological assessments of hippocampal lesions. I am also developing a model for atypical febrile seizures.

    In vitro, we use patch-clamp intracellular recordings of neurons with simultaneous calcium imaging techniques to correlate the neurophysiological changes with fluctuations in intracellular calcium.


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