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Centre de recherche

Defining Pulmonary Progenitors, Development and Diseases

Scientific Conference

Thursday 2 April 2015 from 14:00 at 15:00

Speaker

Melanie Bilodeau, PhD

  • Postdoctoral Research Fellow, Hospital for Sick Children, Toronto

Most pulmonary pediatric diseases remain poorly understood. To define the molecular basis of these diseases, we need to identify the progenitor/stem cell populations and the developmental pathways acting during lung organogenesis and early childhood. Using a new Nkx2-1mCherry reporter mouse model, I isolated a novel population of fetal lung progenitors from the upper airways. These progenitors are a renewable source of specialized epithelial cells to study airway development and diseases in vitro. I also performed whole genome molecular profiling of regional cell subpopulations isolated during murine lung development, leading to the identification of new pulmonary markers and candidate disease pathways. I will discuss how I will follow up on selected pathways relevant to human diseases such as neonatal respiratory distress syndrome, Childhood Interstitial Lung Diseases, asthma, and others. My long lasting interest is to understand how stem and progenitor cells orchestrate complex differentiation programs into various cell/tissue types. I received a Ph.D. degree in molecular biology from Université de Montréal (2007) under the supervision of Dr Guy Sauvageau (2000-2008). During my Ph.D studies, I developed a high-throughput system to perform genome-wide functional genomics in mouse embryonic stem cells. Subsequently, I joined Dr Janet Rossant laboratory (SickKids, Toronto) for a postdoctoral training in developmental and stem cell biology, with a focus on lung progenitors and development (2008-2014).

 
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Updated on 3/31/2015
Created on 3/30/2015
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