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Centre de recherche

Epigenetic Therapy of Cancer

Scientific Conference

Friday 8 May 2015 from 12:00 at 13:00


Jean-Pierre Issa, MD, PhD

  • Professor of Medicine, American Cancer Society Clinical Research
  • Director, Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine

Dr. Issa received his undergraduate training and his M.D. from the American University of Beirut followed by residency in internal medicine at Good Samaritan Hospital and fellowship in Oncology at Johns Hopkins Hospital in Baltimore. He was on the faculty at Johns Hopkins from 1994-1999, at the University of Texas M. D. Anderson Cancer Center from 1999-2011, and is currently Professor of Medicine and Director, Fels Institute for Cancer Research and Molecular Biology at Temple University. Dr. Issa’s laboratory has made important contributions to the understanding of the importance of epigenetics in the pathophysiology and treatment of cancer. Some of his lab’s discoveries include the effects of aging and inflammation on promoter DNA methylation, the CpG Island Methylator Phenotype in multiple cancers, and the interrelations between aberrant DNA methylation and histone modifications in cancer. Starting in 2000, his group initiated laboratory research inspired clinical trials that showed that low doses of hypomethylating drugs specifically target DNA methylation and are optimal in the treatment of leukemias. This work contributed to the FDA approval of decitabine in 2006, and led to a large number of epigenetic therapy clinical trials in different malignancies. His current research focuses on mechanisms of epigenetic alterations in aging and cancer, translation of epigenomic studies for Precision Medicine, development of drugs for reprogramming the epigenome and clinical trials of epigenetic therapy in cancer. Dr. Issa’s research has been recognized by numerous awards including a Sidney Kimmell Foundation Scholar Award in 1997, election to the American Society of Clinical Investigation in 2003, an American Cancer Society Clinical Research Professorship in 2007, the Faculty Achievement Award in Basic Research from MD Anderson in 2007 and the Rosenthal Award from the American Association for Cancer Research in 2011.

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Updated on 5/8/2015
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