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Systems Biology Approaches in Stem Cell Bioengineering and Regenerative Medicine

Scientific Conference

Monday 15 June 2015 from 12:00 at 13:00


  • Rich Carpenedo, PhD, Postdoctoral Fellow, Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute

Pluripotent stem cells hold tremendous potential as a cell source for applications in regenerative medicine, drug screening, and studies of human development; however, efficient generation of mature, functional cell populations from pluripotent stem cells remains a challenge. Production of functional cells relevant to the treatment of degenerative disorders will be aided by a comprehensive, systems-level understanding of mechanisms that regulate stem cell fate decisions, including self-renewal and differentiation. This presentation will describe an unbiased, systems biology approach that elucidated the role of MKRN1 as an RNA binding protein within the mouse embryonic stem cell self-renewal network. Work toward drafting gene regulatory networks in human embryonic stem cell differentiation to a mesendoderm fate will also be discussed. Additionally, efforts to control stem cell differentiation through micro environmental manipulation, as well as the integration of systems-level analyses with stem cell bioengineering approaches will be covered. Dr. Carpenedo earned a Bachelor of Science in Engineering (B.S.E) with a major in Biomedical Engineering from Case Western Reserve University (Cleveland, OH, USA) in 2004. In 2010, he completed his Ph.D. in Bioengineering at the Georgia Institute of Technology (Atlanta, GA, USA) in the laboratory of Dr. Todd McDevitt, working on biomaterials-based approaches to engineer stem cell microenvironments. Richard joined the laboratory of Dr. William Stanford at the University of Toronto in 2010 before the Stanford lab relocated to the Ottawa Hospital Research Institute in 2011. During his postdoctoral training with Dr. Stanford, Richard has worked on drafting gene regulatory networks involved in the differentiation of human embryonic stem cells.

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Updated on 6/15/2015
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