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Centre de recherche

Tuesday 15 January 2019 from 15:00 at 16:00

Histones, histone chaperones and the inheritance of epigenetic information

Scientific Conference of the Unité collaborative en épigénétique moléculaire (UCEM)

Speaker

  • Eric Campos, PhD
    • Assistant Professor, Department of Molecular Genetics, University of Toronto
      Scientist, SickKids Research Institute

Chromatin is organized in nucleosomal particles, where DNA is wrapped around a histone octamer.  Histone proteins are subject to numerous posttranslational modifications, some of which are inherited throughout DNA replication—hence considered to be epigenetic.  How histones and histone chaperone proteins propagate epigenetic information is specifically explored.  Dr. Campos and his team aim to understand the spatiotemporal regulation of epigenetic factors that cells utilize to maintain a transcriptional ‘memory’ through cell division.  Emphasis is not only placed on the biochemical characterization of histones, histone chaperones and the protein complexes that help perpetuate epigenetic information under normal circumstances, but also on how the process goes awry in a number of childhood cancer.

 
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Updated on 1/14/2019
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