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Centre de recherche

Tuesday 18 February 2020 from 09:00 at 10:00

Scientific Conference - Anthony Flamier

Epigenetic Changes in Alzheimer’s Disease

Speaker

  • Anthony Flamier, PhD
    • Chercheur postdoctoral, Laboratoire du Dr Rudolf Jaenisch, Whitehead Institute for Biomedical Research - Massachusetts Institute of Technology
    • Co-fondateur de StemAxon

Alzheimer’s disease (AD) is the most common form of dementia altering primary brain functions. With an increasing number of individuals affected each year, this global health crisis is a priority for health agencies. Despite years of research, no treatment to stop the disease has been found and the cause of the prominent form of the disease (sporadic AD) is still poorly understood. Genetic background is the prime risk factor for developing AD but it can’t explain the majority of the cases. We hypothesize that epigenetic alterations may be the source of AD pathological features with age. I will present two distinct examples of epigenetic defects involved in AD pathology: 1) the downregulation of BMI1, a protein member of the polycomb repressive complex 1 (PRC1); 2) the DNA methylation changes in AD neurons. To investigate these epigenetic variations, I’m using human pluripotent stem cell technologies to generate patient specific neurons and further model the disease in vitro. To profile variations in DNA methylation we chose to perform single-nucleus bisulfite sequencing to clearly depict Differentially Methylated Regions (DMR) of the genome at a single base pair resolution on single cells. Finally, we use a deactivated Caspase 9 coupled to TET1 (to methylate DNA) or DNMT1 (to unmethylate DNA) and a region-specific guide RNA to edit the epigenome and propose therapeutic alternatives. This study may give new insights on the cause of this disease so devastating for the elderly population and their families.

 
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Updated on 3/5/2020
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