• Français
 
Centre de recherche

Friday 14 February 2020 from 12:00 at 13:00

Scientific Conference of Friday Noon

The living Dead: Metabolic Arrest and the control of Biological Time

Speaker

  • Kenneth Storey, PhD, FRSC
    • Professor of Biochemistry, Department of Biology and Department of Chemistry, Carleton University
    • Canada Research Chair in Molecular Physiology

The "Edges of Life" have fascinated thinkers from the time of Aristotle. Environmental extremes trigger extreme animal responses. Stresses, from drying to freezing to oxygen deprivation to extreme heat or cold can trigger 'the living dead" – animals that are alive but show no apparent life signs. For example, from our own perspective as homeotherms that are severely injured if core body temperature drops below ~25°C, it is amazing to think about hibernation – mammals descending into a deep torpor and letting their bodies chill to near 0°C. Nature has set in place complex mechanisms to allow animals to “turn down the fires of life” – the basic framework is present in every organism but discovering the biochemical secrets of how to do this is the challenge. Our lab studies the molecular mechanisms that control metabolic rate suppression. We have identified multiple adaptive strategies that regulate transitions to and from hypometabolism and maintain viability over prolonged dormancy. These include differential gene expression, altered cell signaling pathways, and changes to enzyme properties to alter their function during hypometabolism. This talk will summarize our recent work on the molecular mechanisms of metabolic arrest in mammalian hibernation. Startling similarities exist in basic mechanisms of hypometabolism across phylogeny - indicating, perhaps, that torpor was a basal characteristic of mammals. You, as a human, may have just "forgotten" this skill.

 
About this page
Updated on 1/29/2020
Created on 1/29/2020
Alert or send a suggestion
 

Every dollar counts!

Thank you for your generosity.

It is thanks to donors such as you that we are able to accelerate research discoveries, to heal more children every year and to continue to offer world-class care.

It is also possible to give by mail or by calling toll-free

1-888-235-DONS (3667)

Contact Us

514 345-4931

Legal

© 2006-2014 CHU Sainte-Justine.
All rights reserved. 
Terms of Use,  Confidentiality,  Security

Warning

All information contained within the CHU Sainte-Justine site should not be used as a substitute for the advice of a duly qualified and authorized medical practitioner or any other health professional. The information provided on this site is intended for educational and informational purposes only.

Consult your physician if you feel ill or call 911 for any medical emergency.

CHU Sainte-Justine