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Centre de recherche

Friday 21 February 2020 from 12:00 at 13:00

Scientific Conference of Friday Noon

Wiring the visual system: axon guidance and binocular depth perception

Speaker

  • Frederic Charron, PhD
    • Canada Research Chair in Developmental Neurobiology
    • Professor and Lab Director, Institut de recherches cliniques de Montréal (IRCM)
    • Research Professor, Department of Medicine, Université de Montréal
    • Adjunct Professor, Department of Anatomy & Cell Biology, McGill University

At the optic chiasm choice point, contralateral retinal ganglion cells (RGCs) cross the midline while ipsilateral RGCs are repelled away from the midline by guidance cues. We showed that Sonic Hedgehog (Shh) is produced by contralateral RGCs at the retina, transported anterogradely along the axon, and accumulates at the optic chiasm to repel ipsilateral RGCs. These findings reveal a role for axon-axon interactions in ipsilateral RGC guidance. Our work on the genetic dissection of the role of ipsilateral RGCs in visual depth perception will also be presented.

 
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Updated on 1/31/2020
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