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Centre de recherche

Seminar in epigenetics

Integrating the epigenetic and genetic layers of the Gen3G cohort

Tuesday 18 February 2020 from 15:00 at 16:00


  • Pierre-Étienne Jacques, PhD
    • Assistant Professor, Department of Biology, University of Sherbrooke

The Genetics of Glucose regulation in Gestation and Growth (Gen3G) prospective pre-birth cohort was recruited to investigate the pathophysiology of gestational diabetes and its impact on fetal development and children’s health. Many genome-wide datasets were generated for a subset of ~450 pairs of mother-child. These datasets include genotyping array data of mothers DNA, high-throughput sequencing data of mother’s circulating microRNAs (miRNA-seq) isolated at first trimester of pregnancy, whole-genome sequencing (WGS) of the children, as well as DNA methylation (DNAm) array data of fetal placenta and cord blood.

During this talk, I will present the tissue-specific differentially methylated regions (tDMR) that we identified and how they informed us on novel placenta-specific genomic regions harboring genes of potential importance to understand its unique physiology. I will also present preliminary results on the identification of methylation quantitative trait loci (mQTL), as well as our efforts to identify miRNA allelic imbalance and fetal origin events that we are investigating.

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Updated on 2/17/2020
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