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Centre de recherche

Scientific Conference of Friday Noon - Alexandre Dubrac

Vascular heterogeneity in the neurovascular unit

Friday 26 March 2021 from 12:00 at 13:00

Speaker

  • Alexandre Dubrac, PhD
    • Assistant professor under grant, Department of pathology and cell biology, University of Montreal

The neurovascular unit (NVU) is essential for the blood-retina/brain barrier (BRB and BBB), a unique and highly selective barrier that regulates the exchange between the blood and the brain/retina in order to protect neuronal homeostasis. Disruption of the BRB/BBB is involved in the onset and the progression of several pathologies of the central nervous system, including retinopathies and Alzheimer's disease. The NVU is composed of endothelial cells (ECs) lining the bloodstream, pericytes, and astrocytes. While the vascularization of both the brain and retina is led by the permeability-inducing growth factor VEGFA, ECs establish the BRB/BBB early during vascular development. How ECs coordinate sprouting and barriergenesis remain unknown. My lab is interested in deciphering these organotypic features using single-cell RNA sequencing and unique transgenic mouse models. We have recently identified a new specialized neuronal endothelial tip cell, which guides retinal and brain vascularization, and displays BRB/BBB properties and TGFb signaling requirements. Our data reveal stage-specific tip cell heterogeneity as a requirement for retinal and brain vascular development and suggest that TGFb signaling could improve neuronal tissue revascularization in retinal and brain ischemic diseases.

Zoom Conference

https://chusj.zoom.us/j/85492132878
Password: 140613

 
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Updated on 4/8/2021
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