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Centre de recherche

Scientific Conference of Friday Noon - Lucien Weiss

Throughput or resolution, why not both? Tracking nanoscale 3D changes in populations of flowing cells

Friday 10 September 2021 from 12:00 at 13:00


  • Lucien Weiss, PhD
    • Assistant Professor, Department of Engineering Physics, Polytechnique Montréal
    • Member, Biomedical Engineering Institute
    • Researcher, TransMedTech Institute

Attaining three-dimensional data at high throughput is a grand challenge in microscopy. Here we demonstrate a novel solution that enables the collection of 3D positions in thousands of cells each minute by merging two technologies in fluorescence microscopy: point-spread-function engineering and imaging flow cytometry. We have applied our approach to monitor DNA compaction in yeast and to characterize the uptake of nanoparticles in cancer cells. Finally, I will discuss how our new lab at Polytechnique plans to develop a suite of flow-based measurements in tandem to probe biomolecular interactions over a broad range of scales, from single-molecule affinities to cellular drug resistance.


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Updated on 8/31/2021
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