Conférence scientifique du vendredi midi - François Jean || 28 avril

Pre-clinical development of novel mono- and combination drug therapies for global viral pandemic preparedness based on host-directed antivirals

vendredi 28 avril 2023 de 12:00 à 13:00

CONFÉRENCE SCIENTIFIQUE DE L'AXE Maladies infectieuses et soins aigus 

Conférencier

• Dr François Jean, PhD

  Professeur de virologie
  Lead, Pillar 10, CoVaRR-net – Antiviral strategies & antiviral therapeutics
  Fondateur, UBC CL3 Facility for Infectious Disease and Epidemic Research (FINDER)
  Department of Microbiology and Immunology, University of British Columbia, Vancouver

Résumé

Emerging human viruses such as SARS-CoV-2, influenza A virus, and Zika virus have had an enormous impact on human health and are now identified by the World Health Organization as Public Health Emergencies of International Concern. Although there is currently no treatment available for Zika-related microcephaly, antivirals continue to be important clinical tools for limiting the impact of respiratory viral infections associated with SARS-CoV-2 and Influenza A since both viruses continue to evolve and thus escape natural and vaccine-mediated immunity. Importantly, no broad-spectrum antiviral drugs are available that can prevent and treat infections caused by these three viruses and are desperately needed.

Dr. Jean will present the recent discovery of novel pan- and cross-viral therapeutics directed at host-cell enzymes. He will discuss their applications as host-directed antivirals (HDAs) when used alone or in combination in 2D and 3D cell-based systems of viral infection. This work will provide new insights into the unique biology of emerging and re-emerging human pathogenic viruses, and unravel potential combination antiviral therapies based on HDAs acting synergistically as alternatives to monotherapy to improve viral-disease treatment.

Date et lieu

Vendredi 28 avril 12h à 13h

• En présence: Amphithéâtre Justine-Lacoste-Beaubien
• En virtuel: inscription obligatoire (cliquer ici)