Centre de recherche
Conférence scientifique du vendredi midi - Andrew O. Agbaje || 31 mars
Determinants of carotid intima-media thickness and arterial stiffness in pediatrics: lessons learned from the ALSPAC cohort
vendredi 31 mars 2023 de 12:00 à 13:00
CONFÉRENCE SCIENTIFIQUE DE L'AXE Santé métabolique et cardiovasculaire
Conférencier
- Andrew O. Agbaje, MD, MPH
- Cert. Clinical Research (Harvard)
- Chercheur principal du groupe de recherche urFIT-CHILD
- Médecin et épidémiologiste clinique à l'Institute of Public Health and Clinical Nutrition, École de médecine, Faculté des sciences de la santé, University of Eastern Finland, Campus Kuopio.
Résumé
Among adults arterial stiffness and carotid intima-media thickness (cIMT), intermediate markers of arteriosclerosis and atherosclerosis, are strong predictors of cardiovascular events. Several childhood risk factors such as elevated and hypertensive blood pressure, insulin resistance, hyperglycemia, obesity, and dyslipidemia have been associated with the risk of higher arterial stiffness and cIMT in mid-life (~age 45 years). In pediatric clinical population, arterial stiffness and cIMT are indicators of premature vascular organ damage and evidence for initiating treatment interventions. The paucity of normative longitudinal data and repeated gold-standard assessments of arterial stiffness and cIMT among the young population substantially decreased the clinical utility of these vascular measures.
In the last 3 years, large-scale longitudinal reports have helped clarify the roles of childhood risk factors on arterial stiffness and cIMT measured once in adolescence or young adulthood. Moreover, the availability of repeated vascular measures provided the opportunity to investigate the effect of cumulative modifiable risk factors measured from childhood through young adulthood on vascular progression (increase or decrease) from adolescence through young adulthood.
Ten years ago, it was reported among US adults that altered vascular indices such as arterial stiffness preceded elevated blood pressure and incident hypertension in the causal path. Eight years later (two years ago), arterial stiffness was also shown to temporally precede incident type 2 diabetes in Chinese adults, now confirmed in UK and US adults. In recent months (~1 year ago), the temporal causal nature of arterial stiffness and cIMT in relation to elevated and hypertensive blood pressure, insulin resistance, hyperglycemia, obesity, dyslipidemia, and inflammation have been investigated among adolescents and young adults.
These recent analyses were conducted using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, in England, UK. ALSPAC investigates factors that influence childhood development and growth. In this scientific conference series, the longitudinal determinants of arterial stiffness and cIMT in healthy adolescents, and young adults, and the vascular progression during growth from adolescence through young adulthood would be discussed. Moreover, evidence of temporal causal associations between vascular measures and these determinants would be presented.
Date et lieu
Vendredi 31 mars de 12h à 13h
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