Biography

Energy metabolism and cancer
Using genetics, Jiang Wei Wu and her team completely blocked the breakdown of fat in mice. This condition has never been achieved before. Surprisingly, the mice were not obese, but developed a cancer called sarcoma in their fat.

This discovery may reveal new treatable pathways for cancer development in children and adults.

Awards and Distinctions

• 2012, Postdoctoral Scholarships for Excellence, Fondation CHU Sainte-Justine
• 2012, Postdoctoral Training for Foreign Applicants, FRQS, University of Montréal
• 2012, Best Oral Presentations, All Categories, CHU Sainte-Justine
• 2011, Best doctoral dissertation
• 2011, Best doctoral publication
• 2008, Scholarship for Joint International Studies, China Scholarship Council
• 2006, Excellent postgraduate dissertation
• 2004, Scholarship, "Liu He" Company
• 2003, Scholarship, "He Feng" Company
• 2003, Excellent undergraduate dissertation
• 2006, Excellent Student Representative
• 2003, Excellent Postgraduate studentship
• 1999, Excellent Tri-A Student

Presentations

• Jiang Wei WU, Shu Pei Wang, Nicolas Gauthier, Stéphanie Casavant, Alain Moreau, Gong She Yang, and Grant A. Mitchell. Fasting energy homeostasis in mice with adipose deficiency of adipose triglyceride lipase. XXVIIe congrès de la recherche des étudiants gradués et post-gradués du Centre de recherche du CHU Sainte-Justine, Montréal, QC. May 30, 2012.
• Yang Gongshe, Wu Jiang Wei and Bai Liang. Gene knockout pig is a promising model to study human disease. 16th National Animal Breeding and Genetics Symposium, Jiangsu, Yangzhou, China, May, 2011.
• Jiang Wei Wu, Shu Pei Wang, Fernando Alvarez, Stephanie Casavant, Nicolas Gauthier, Lynda Abed, Krishnakant G. Soni, Gongshe Yang, and Grant A. Mitchell. Hepatocyte-Specific Deficiency of Adipose Triglyceride Lipase (ATGL) in Mice Causes Liver Steatosis. XXVème Congrès annuel de la recherche des étudiants gradués et post-gradués du Centre de recherche, CHU Sainte Justine, Montréal, QC. May 2010.
• Yang Gongshe, Wu Jiang Wei, Wang Bo, Zhang Hao Wei. Mouse and pig fat cell culture and biology study. 9th Chinese Cell Biology Conference, GuangZhou, Guang Dong, China. Nov.2007.
• Yang Gongshe, Wu Jiang Wei, Wang Bo, Zhuang Hao Wei. SOCS3 is an obesity target in mice and pigs. Chinese Society for Cell Biology Committee of Medical Cell Biology (Jiangsu, Zhejiang, Fujian Institute of Cell Biology, Academic Conference). 2006.

Publications

• Wu, J.W., Wang, S.P. et al (2012). ''Fasting energy homeostasis in mice with adipose deficiency of desnutrin/adipose triglyceride lipase'' Endocrinology. 153(4):2198-2207
• Wu, J.W., Wang, S.P. et al (2011). ''Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis'', Hepatology. 54 (1), 122-32
• Wu, J.W., Wang, B. et al (2007). ''Different transcription profiles of SOCS-3, OB and IGF-I genes and their possible correlations in obese and lean pigs'', Acta Biochim Biophys Sin. 39 (4), 305-10.
• Gauthier N., Wu J.W., et al (2013). ''A liver-specific defect of acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic acyl-CoA pattern'', Plos one. In press.
• Wang S.P., Wu J.W., et al (2013). ''Enzymatic Activity, but Not the Testes-Specific N-Terminal Region of Hormone-Sensitive Lipase is Necessary for Male Mice Fertility'', Endocrinology. Submitted.
• Yang, S.J., Xu, C.Q., Wu, J.W. et al (2010). ''SOCS3 inhibits insulin signaling in porcine primary adipocytes'', Molecular and Cellular Biochemistry. 345(1-2), 45-52.